Clinical factors associated with unipolar mania: A systematic review and meta-analysis

Introduction The existence of a clinical entity on the spectrum mood disorders characterized by occurrence manic episodes without major depressive (Unipolar Mania, UM) is largely debated. Although not classified nosologically, studies exploring this topic have suggested that UM might differ from bipolar disorder with manic-depressive course (md-BD), in terms several characteristics. Individuals represent subpopulation specific profiles and unmet care needs, requiring personalized treatments, as compared those suffering md-BD. Objectives To identify factors associated UM, Methods We performed systematic review meta-analysis observational according to MOOSE guidelines. searched for articles indexed up July 2022 main electronic databases. conducted random-effects meta-analyses association between relevant correlates, using odds ratio categorical variables standardized mean difference continuous variables. Results Based data 21 meeting eligibility criteria, we found individuals md-BD, were more likely be males (p = 0.007) an earlier age at onset 0.020). Moreover, was significantly higher number hospitalizations < 0.001), psychotic features well hyperthymic temperament 0.012). Finally, subjects less report family history depression 0.006) personal suicide attempts 0.001). Conclusions Our work supports hypothesis distinctive diagnostic construct, peculiar correlates. Additional research needed better differentiate context affective disorders. Disclosure Interest None Declared